The paper presents the results of long-term, homogeneous spectroscopic studies of the Herbig Ae/Be star HD 141569A, obtained in the optical range. We detect spectral variability on timescales of months to years, including changes in the spectrophotometric parameters of the Hα emission line, as well as other hydrogen absorption lines. Based on the derived physical parameters and age, the star appears to be in a transitional evolutionary stage—from a protoplanetary disk to a debris disk. We determine that the star’s axial rotation period is approximately 12 hr, and its equatorial velocity is significantly below the critical rotation velocity. The observed spectral variability is likely caused by partial obscuration of the central star’s radiation by extended fragments of the disrupted disk.