Abstract Glycine C2H5NO2 is the first amino acid, used by living organisms to makeproteins, which was detected in space by the Stardust Space Probe in Comet Wild2. In thepresent paper, we have discussed three different reaction paths for the formation of glycine inInterstellar space from some simpler molecules detected in Interstellar medium. The possibilityof the formation of glycine in the Interstellar space is considered by radical-radical andradical-molecule interaction schemes using quantum chemical calculations with density functionaltheory (DFT) at the B3LYP/6-31G (d,p) level. In the discussed chemical pathways, afew reactions are found to be totally exothermic and barrier less while others are endothermicwith a very small reaction barrier, thus giving rise to a high probability of glycine formationin Interstellar space
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